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GLP-1 receptor agonist medications solve this by using modified versions of the GLP-1 molecule that resist enzymatic breakdown
The REWIND cardiovascular outcome trial also revealed that dulaglutide administration resulted in inferior ocular outcomes, leading to an increased need for interventions such as photocoagulation, anti-vascular endothelial growth factor (VEGF) therapy, or vitrectomy compared to placebo recipients [38]
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For example, Muayad et al compared 61,998 patients with diabetes using GLP-1 RAs with metformin users in the US Collaborative Network of the TriNetX EHR database to calculate the risk of developing ocular hypertension or primary open-angle glaucoma, requiring topical glaucoma medication, or requiring laser trabeculoplasty
This is rare at therapeutic doses and the on-demand dosing schedule (max 8x/month), but it's worth mentioning given PT-141's origins in tanning peptide research
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